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M94A0226.TXT
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1994-10-08
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Document 0226
DOCN M94A0226
TI Immunologic status in patients infected with HIV with oral candidiasis
and hairy leukoplakia.
DT 9412
AU Kolokotronis A; Kioses V; Antoniades D; Mandraveli K; Doutsos I;
Papanayotou P; School of Dentistry, Aristotle University of
Thessaloniki,; Specific Infectious Disease Unit, Greece.
SO Oral Surg Oral Med Oral Pathol. 1994 Jul;78(1):41-6. Unique Identifier :
AIDSLINE MED/94359691
AB Although numerous studies of oral manifestations associated with HIV
have been reported, only a few refer to the correlation of these lesions
with laboratory parameters. In this study we investigated the
relationships between the two most common HIV-associated oral lesions,
oral candidiasis and hairy leukoplakia, with the stage of the disease,
circulating CD4+ cell counts, and the presence of anti-p24 antibodies in
serum and stimulated whole saliva in 43 known HIV-1-infected persons.
Although oral candidiasis and hairy leukoplakia were exclusively
observed in subjects who were classified as Centers for Disease Control
and Prevention group IV, only the prevalence of oral candidiasis is
strongly associated with circulating CD4+ counts less than 200/mm3 (p <
0.02). The prevalence of oral candidiasis and hairy leukoplakia was
significantly related to the absence of anti-p24 antibodies in serum (p
< 0.01 and p < 0.01, respectively), but was only statistically
significant for hairy leukoplakia in stimulated whole saliva (p < 0.02).
The results suggest that oral candidiasis and hairy leukoplakia in
correlation with immunologic status as indicated by low circulating CD4+
cell counts and the absence of anti-p24 antibodies in serum and the loss
of secretory anti-p24 antibodies in subjects with hairy leukoplakia, may
constitute prognostic markers for the progression of HIV-infection to
AIDS. Our results also indicate that the absence of anti-p24 antibodies
is not only influenced by the low levels of circulating CD4+ cells but
probably by the presence of oral candidiasis or hairy leukoplakia as
well.
DE Adolescence Adult AIDS-Related Opportunistic
Infections/BLOOD/*IMMUNOLOGY Biological Markers Candidiasis,
Oral/BLOOD/ETIOLOGY/*IMMUNOLOGY Chi-Square Distribution CD4-CD8 Ratio
Female Human HIV Antibodies/BLOOD HIV Core Protein p24/IMMUNOLOGY
Leukoplakia, Hairy/BLOOD/ETIOLOGY/*IMMUNOLOGY Male Middle Age
Prevalence Prognosis Saliva/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).